The MRI protocol and segmentation procedure has been described elsewhere [13 (link), 28 (link)]. In short, eligible participants underwent MRI on a 1.5T Signa Twinspeed system (General Electric Medical Systems, Waukesha, WI) including a 3-dimensional axial T1-weighted spoiled gradient echo sequence, a fluid attenuated inversion recovery (FLAIR) sequence, a proton density/T2-weighted (PD/T2) fast spin echo sequence, and a T2*-weighted gradient echo type echoplanar sequence. The FLAIR, PD/T2 and T2* sequences were acquired with 3mm thick interleaved slices. Regional gray and white matter, CSF and lesions were segmented automatically with an AGES-Reykjavik Study modified algorithm described elsewhere [28 (link)]. Infarcts were rated by trained radiographers.
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MRI Segmentation and Lesion Analysis Protocol
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Corresponding Organization : National Institute on Aging
Other organizations : Reykjavík University, National University Hospital of Iceland, University of Iceland, Icelandic Heart Association
Top 5 similar protocols
Variable analysis
independent variables
- MRI protocol
- Regional gray and white matter
- CSF and lesions
- Infarcts
- 1.5T Signa Twinspeed system (General Electric Medical Systems, Waukesha, WI)
- 3-dimensional axial T1-weighted spoiled gradient echo sequence
- Fluid attenuated inversion recovery (FLAIR) sequence
- Proton density/T2-weighted (PD/T2) fast spin echo sequence
- T2*-weighted gradient echo type echoplanar sequence
- 3mm thick interleaved slices
- AGES-Reykjavik Study modified algorithm
- Infarcts were rated by trained radiographers.
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