Venlafaxine (Sigma Aldrich, St. Louis, MO, USA), a serotonin-norepinephrine reuptake inhibitor (SNRI) anti-depressant, was dissolved in normal saline [40 (link)]. Anti-IL-17 (Bioxcell, Lebanon, NH, USA) and IgG (Bioxcell) was dissolved in purified dilution buffer [59 (link)]. The mice were treated with Venlafaxine (10 mg/kg, once a day for 3 weeks, i.p) or Anti-IL-17 (100 μg/mouse, once every 3 days for 2 weeks, i.p). The same volume of saline or IgG was administrated to mice in the vehicle group, respectively.
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