CBD Supplementation in Dog Trials

Dogs received either a placebo or CBD capsule (~4 mg/kg bodyweight) within a Royal Canin^® Pill Assist pocket, with their morning meal. Hemp-derived distillate and placebo oils were acquired from Canopy Growth Corporation (Ontario, Canada) and processed by Kazmira LLC (Colorado, USA). The distillate was diluted with a food-grade sunflower oil and manufactured in soft gel capsules (bovine origin; RNA Corporation, Illinois, USA). Capsules were then analyzed for potency and purity as previously described (40 (link)), finding only trace amounts of non-psychoactive cannabidivarin (0.004 mg CBDV/mg of CBD) in a small number of capsules, and no detectible THC or other cannabinoids. The placebo soft gel capsules were manufactured to match the conformity of the CBD-containing capsules, minus the CBD, to maintain the blinding of the study. Two hours after placebo/CBD administration had been confirmed, dogs were exposed to either the separation event or car travel.

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Hunt A.B., Flint H.E., Logan D.W, & King T. (2023). A single dose of cannabidiol (CBD) positively influences measures of stress in dogs during separation and car travel. Frontiers in Veterinary Science, 10, 1112604.

Publication 2023

Bodyweight Bovine Cannabinoids Capsules Cbdv Dogs Food Hemp Oils Pill Placebo Sunflower oil

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Variable analysis

independent variables

Placebo capsule
CBD capsule (~4 mg/kg bodyweight)

dependent variables

Exposure to separation event
Exposure to car travel

control variables

Capsules were administered within a Royal Canin® Pill Assist pocket, with the dogs' morning meal
Placebo soft gel capsules were manufactured to match the conformity of the CBD-containing capsules, minus the CBD, to maintain the blinding of the study
Capsules were analyzed for potency and purity, finding only trace amounts of non-psychoactive cannabidivarin (0.004 mg CBDV/mg of CBD) in a small number of capsules, and no detectible THC or other cannabinoids

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