Qishenkeli Herbal Extraction Protocol

The QSKL used in this study is manufactured by Beijing university of Chinese medicine (Beijing, China) using the six Chinese herbs at a composition of 460 g Radix Astragali Mongolici, 230 g salvia miltiorrhiza bunge, 160 g Flos Lonicerae, 160 g scrophularia, 140 g Radix Aconiti Lateralis Preparata, and 90 g Radix Glycyrrhizae. Briefly, the residue of Radix Astragali Mongolici is mixed with all salvia miltiorrhiza bunge, Flos Lonicerae, scrophularia, and Radix Glycyrrhizae, follow by extraction with hot water (twice, 2 hr each). The water extract is then concentrated to form a paste, and the ethanol is added for 24 hr, the filtration is collected to form the final product. Based on the recommended daily human dosage of 20 g/d, according to the equivalent conversion between animal and people by body surface area, dosage of 508 mg/kg is chosen in present study.

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Wang Y., Liu Z., Li C., Li D., Ouyang Y., Yu J., Guo S., He F, & Wang W. (2012). Drug Target Prediction Based on the Herbs Components: The Study on the Multitargets Pharmacological Mechanism of Qishenkeli Acting on the Coronary Heart Disease. Evidence-based Complementary and Alternative Medicine : eCAM, 2012, 698531.

Publication 2012

Animal Body surface area Chinese Ethanol Filtration Flos Human Medicine Paste Radix Radix aconiti Radix astragali Salvia miltiorrhiza Scrophularia

Corresponding Organization : Beijing University of Chinese Medicine

Other organizations : Beijing Proteome Research Center

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Variable analysis

independent variables

Dosage of QSKL (508 mg/kg)

dependent variables

Not explicitly mentioned

control variables

Composition of QSKL (460 g Radix Astragali Mongolici, 230 g Salvia Miltiorrhiza Bunge, 160 g Flos Lonicerae, 160 g Scrophularia, 140 g Radix Aconiti Lateralis Preparata, 90 g Radix Glycyrrhizae)
Manufacturing process of QSKL (Residue of Radix Astragali Mongolici mixed with other herbs, extracted with hot water, concentrated, and added with ethanol for 24 hr)

controls

No positive or negative controls were explicitly mentioned in the information provided.

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