Evaluating Tumor Glucose Metabolism with PET/CT

PET/CT imaging of ¹⁸F-FDG was used to assess glucose metabolism. Referring to previous studies [27 (link), 29 (link)], patients fasted for 6–8 h before intravenous injection of ¹⁸F-FDG (3.7–4.1 MBq/kg). After 50 min of drug injection, PET/CT imaging was performed with Biograph mCT 64 system (Siemens Healthcare, Germany). Experienced nuclear medicine doctors draw the region of interest (ROI) around the tumor, and automatically calculate and record the maximum and mean standardized uptake value (SUVmax and SUVmean), total lesion glycolysis (TLG) and metabolic tumor volume (MTV) of each ROI through the system.

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Liu X.S., Yuan L.L., Gao Y., Ming X., Zhang Y.H., Zhang Y., Liu Z.Y., Yang Y, & Pei Z.J. (2023). DARS2 overexpression is associated with PET/CT metabolic parameters and affects glycolytic activity in lung adenocarcinoma. Journal of Translational Medicine, 21, 574.

Publication 2023

Biograph mCT 64 system

18f fdg Drug Glucose Glycolysis Medicine doctors Metabolism Patients Pet ct Tumor

Corresponding Organization :

Other organizations : Hubei University of Medicine, Taihe Hospital

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Variable analysis

independent variables

Fasting duration (6-8 hours)

dependent variables

Maximum standardized uptake value (SUVmax)
Mean standardized uptake value (SUVmean)
Total lesion glycolysis (TLG)
Metabolic tumor volume (MTV)

control variables

Intravenous injection of 18F-FDG (3.7-4.1 MBq/kg)
Time between drug injection and PET/CT imaging (50 minutes)
PET/CT imaging system (Biograph mCT 64, Siemens Healthcare, Germany)
Region of interest (ROI) drawn by experienced nuclear medicine doctors

controls

Positive control: None specified
Negative control: None specified

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