Characterization of Nanomaterial Properties

Photon Correlation Spectroscopy (PCS) was used to evaluate the mean diameter, size distribution and zeta potential of the systems using a 1:50 dilution and applying the third-order cumulant fitting correlation function (Zetasizer Nano ZS apparatus, Malvern Panalytical Ltd., Spectris plc, Malvern, UK) [37 (link)]. Transmission Electron Microscopy (TEM) was used in order to investigate the morphology of the nanosystems, as previously described [35 (link),37 (link)].
Moreover, a Turbiscan Lab Expert^® apparatus (Formulaction, Toulouse, France) was employed with the aim of evaluating the stability of the various samples; the results were processed using Turby Soft 2.0 software (Formulaction, Toulouse, France) and expressed as Turbiscan Stability Index (TSI) as a function of time and temperature [35 (link),38 (link)].

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Voci S., Gagliardi A., Ambrosio N., Salvatici M.C., Fresta M, & Cosco D. (2023). Gliadin Nanoparticles Containing Doxorubicin Hydrochloride: Characterization and Cytotoxicity. Pharmaceutics, 15(1), 180.

Publication 2023

Zetasizer Nano ZS apparatus

Dilution Photon correlation spectroscopy Transmission electron microscopy

Corresponding Organization : Magna Graecia University

Other organizations : Institute for the Chemistry of OrganoMetallic Compounds, National Research Council

Top 5 similar protocols

Variable analysis

independent variables

Dilution (1:50)

dependent variables

Mean diameter
Size distribution
Zeta potential
Morphology

control variables

Zetasizer Nano ZS apparatus (Malvern Panalytical Ltd., Spectris plc, Malvern, UK)
Turbiscan Lab Expert® apparatus (Formulaction, Toulouse, France)
Turby Soft 2.0 software (Formulaction, Toulouse, France)

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