Quantifying Amyloid Accumulation with 11C-PiB PET

PET scans with carbon 11 (¹¹C)–labeled Pittsburgh compound B were performed by using a GE scanner (Advance PET; GE Healthcare, Milwaukee, Wis) in a subset of 119 study participants (Table 2). Distribution volume ratio images were generated by using a method reported by Bilgel et al (23 (link)). Mean cortical distribution volume ratio was calculated as an index of cortical ¹¹C Pittsburgh compound B retention to quantify amyloid accumulation (see Appendix E1 [online]).

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Lin Z., Sur S., Soldan A., Pettigrew C., Miller M., Oishi K., Bilgel M., Moghekar A., Pillai J.J., Albert M, & Lu H. (2019). Brain Oxygen Extraction by Using MRI in Older Individuals: Relationship to Apolipoprotein E Genotype and Amyloid Burden. Radiology, 292(1), 140-148.

Publication 2019

Advance PET

Amyloid Carbon 11 Cortical Pet scans Pittsburgh compound b Retention

Corresponding Organization :

Other organizations : Johns Hopkins University, Johns Hopkins Medicine, National Institute on Aging, National Institutes of Health, Kennedy Krieger Institute

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Variable analysis

independent variables

PET scans with carbon 11 (¹¹C)–labeled Pittsburgh compound B

dependent variables

Mean cortical distribution volume ratio as an index of cortical ¹¹C Pittsburgh compound B retention to quantify amyloid accumulation

control variables

GE scanner (Advance PET; GE Healthcare, Milwaukee, Wis) used in a subset of 119 study participants

controls

No positive or negative controls were explicitly mentioned.

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