Data were extracted on all adult surgical admissions to hospital (CHKS data) and to the ICU (ICNARC data) for 94 NHS hospitals in England, Wales and Northern Ireland between January 1999 and October 2004 inclusive. These hospitals were selected because they contributed to both databases throughout the study period. Admissions involving endoscopy, day-case surgery, cardiothoracic surgery, neurosurgery, organ transplantation, obstetrics or the surgical management of burns were excluded. For brevity, procedures that satisfied the inclusion criteria are described as general surgical procedures.
There are 6,920 surgical procedure codes in the Office of Population Censuses and Surveys (now part of Office for National Statistics and Surveys) classification. Surgical admissions to hospital were identified in the CHKS database by the presence of one of 4,910 codes that satisfied the inclusion criteria. Where more than one surgical procedure was performed during the same hospital admission, only the first procedure was included in the analysis. Several alternative Office of Population Censuses and Surveys codes may exist for any given procedure. In order to reduce bias arising from discrepancies in the coding process, procedures were categorised into one of 372 Healthcare Resource Groups (HRGs) based on clinical similarity and resource homogeneity. Many Office of Population Censuses and Surveys codes and HRG codes specify the presence of a complicating medical condition, the complexity of surgery or a particular age group. HRGs were then ranked according to mortality rates. High-risk surgical procedures were prospectively defined as those procedures included in an HRG with a mortality rate of 5% or more. The remaining procedures were classified as standard risk.
Surgical admissions to the ICU were identified in the ICNARC database by the source of admission (either operating theatre or operating theatre via ward), and were only included if the primary reason for admission was not an excluded surgical procedure. ICU admissions were prospectively divided into admissions directly to the ICU following surgery and admissions to the ICU following a period of postoperative care on a standard ward. Where patients were readmitted to the ICU, only the first admission was included in the analysis.
Data are presented as the median (interquartile range). Categorical data were tested with the chi-squared approximation, and continuous data were tested with the Mann–Whitney U test. Analysis was performed using GraphPad Prism version 4.0 (GraphPad Software, San Diego, CA, USA). Significance was set at P < 0.05.