Multimodal MRI Protocol for MS Evaluation

All subjects underwent MRI on the same scanner (3T Signa; General Electric, Milwaukee, WI, USA) using a consistent acquisition protocol. Brain and cervical spinal cord MRI was performed with the following relevant parameters: brain: coronal 3D modified driven equilibrium Fourier transform (MDEFT) covering the whole head: TR = 7.9 ms, TE = 3.14 ms, flip angle = 15°, slice thickness = 1.6 mm, pixel size = 0.938 × 0.938 mm; axial T2-weighted fast fluid-attenuated inversion-recovery (FLAIR): TR = 9000 ms, TE = 151 ms, TI = 2250 ms, slice thickness = 2 mm, pixel size = 0.976 × 0.976 mm; spinal cord: axial T2-weighted fast spin-echo images of the entire spinal cord: TR = 6117 ms, TE = 110 ms, slice thickness = 3 mm (no inter-slice gaps), pixel size = 0.937 × 0.937 mm. The FLAIR sequence was chosen for the depiction of CLs, based on the effectiveness shown in our previous study (27 (link)). We also paired the FLAIR with a high-resolution T1-weighted sequence per our previous strategy to assure accuracy of the identification of CLs and limit false positives (27 (link)). The MDEFT was chosen as the T1-weighted sequence, given its effectiveness in gray vs. white structural tissue definition (38 (link)) and its high sensitivity to MS lesions, based on our previous work (38 (link)).

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Yousuf F., Kim G., Tauhid S., Glanz B.I., Chu R., Tummala S., Healy B.C, & Bakshi R. (2016). The Contribution of Cortical Lesions to a Composite MRI Scale of Disease Severity in Multiple Sclerosis. Frontiers in Neurology, 7, 99.

Publication 2016

3T Signa

Brain Cervical spinal cord Echo Electric Head Inversion Sensitivity Sequence inversion Spinal cord Tissue

Corresponding Organization : Harvard University

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Cortical lesions (CLs)

control variables

MRI scanner: 3T Signa; General Electric, Milwaukee, WI, USA
Acquisition protocol: consistent for brain and cervical spinal cord MRI
Brain MRI: coronal 3D modified driven equilibrium Fourier transform (MDEFT), axial T2-weighted fast fluid-attenuated inversion-recovery (FLAIR)
Spinal cord MRI: axial T2-weighted fast spin-echo images of the entire spinal cord

controls

Positive control: FLAIR sequence effectiveness for depiction of CLs, based on previous study (27)
Positive control: Pairing FLAIR with high-resolution T1-weighted sequence (MDEFT) to assure accuracy of CL identification and limit false positives, based on previous strategy (27)

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