Tretinoin Gel Formulation and Preparation

Example 2

A composition comprising Tretinoin as an active ingredient:

The process for the preparation of the composition was as follows:

• • 1. Trolamine, Natrosol (HEC) and xanthan gum were added gradually to the water while stirring at high speed using mixer propeller;
  • 2. The mixture of oleic acid, isopropanol, BHT, sorbic acid and tretinoin was heated to 50° C. while stirring then cooled to the room temperature;
  • 3. Silica microspheres were added to the stage 2 and the resultant mixture was stirred for at least one hour;
  • 4. Benzyl alcohol and Glycerin were added to stage 1
  • 5. Stage 4 was added to the mixer reactor and stirred vigorously.

An opaque yellowish gel was obtained.