Protocol detail

Multimodal Brain Imaging Protocol

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T1-weighted imaging and diffusion imaging data were obtained using the same protocol at either the Aberdeen study site (3T Philips Achieva TX-series MRI system Philips Healthcare, Best, the Netherlands) or the Dundee study site (Siemens 3T Prisma-FIT Siemens, Erlangen, Germany). T1 scans were processed using FreeSurfer 5.3.0 and the Desikan–Killiany atlas [22 (link)] was used for subcortical segmentation and cortical parcellation. FA and MD for white matter tracts were derived using TBSS toolkit within FSL following the ENIGMA DTI analysis protocol (http://enigma.ini.usc.edu/protocols/dti-protocols/). The John Hopkins University white matter atlas [23 (link)] was used to define white matter tracts. Full details on image acquisition and quality control measures are described in the Supplementary Materials and elsewhere [20 (link), 24 (link), 25 (link)].

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Thng G., Shen X., Stolicyn A., Harris M.A., Adams M.J., Barbu M.C., Kwong A.S., Frangou S., Lawrie S.M., McIntosh A.M., Romaniuk L, & Whalley H.C. (2022). Comparing personalized brain-based and genetic risk scores for major depressive disorder in large population samples of adults and adolescents. European Psychiatry, 65(1), e44.

Publication 2022

Achieva TX-series MRI system 3T Prisma-FIT

Cortical Diffusion Prisma Scans White matter

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Variable analysis

independent variables

MRI scanner used (3T Philips Achieva TX-series or Siemens 3T Prisma-FIT)

dependent variables

T1-weighted imaging data
Diffusion imaging data
Fractional anisotropy (FA) of white matter tracts
Mean diffusivity (MD) of white matter tracts

control variables

Participants scanned at either the Aberdeen or Dundee study site
T1 scans processed using FreeSurfer 5.3.0
Desikan–Killiany atlas used for subcortical segmentation and cortical parcellation
TBSS toolkit within FSL used to derive FA and MD for white matter tracts
John Hopkins University white matter atlas used to define white matter tracts

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