Protocol detail

Pharmacophore Screening for Pancreatic Cancer

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The three-dimensional structural pattern map of Taxifolin was submitted to PharmMapper (http://www.lilab-ecust.cn/pharmmaDper/), an online website for structural target analysis and screening of pharmacophore. We selected a library of pharmacophore models for screening. To identify the relevant genes associated with pancreatic cancer, we downloaded the gene data obtained from the GeneCards database (https://www.genecards.org/). The intersection of two results yields the target gene.

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Chen S.J., Ren L.K., Fei X.B., Liu P., Wang X., Zhu C.H, & Pan Y.Z. (2024). A study on the role of Taxifolin in inducing apoptosis of pancreatic cancer cells: screening results using weighted gene co-expression network analysis. Aging (Albany NY), 16(3), 2617-2637.

Publication 2024

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Variable analysis

independent variables

Three-dimensional structural pattern map of Taxifolin

dependent variables

Relevant genes associated with pancreatic cancer

control variables

Pharmacophore models library for screening
Gene data obtained from the GeneCards database

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