Thermal Analysis of PCL Nanocapsules

DSC analyses were performed using a TA Q20 calorimeter equipped with a cooling system. Indium was employed for calibration, and samples were heated from −10 °C to 300 °C at a rate of 10 °C·min⁻¹ under a nitrogen flow. Five milligrams of each sample were placed in aluminum pans for analysis, with an empty pan serving as a reference [46 (link)]. The samples subjected to analysis included poly(epsilon-caprolactone) nanocapsules (Nano), lidocaine encapsulated in poly(epsilon-caprolactone) nanocapsules (LDC-Nano), poly(epsilon-caprolactone) (PCL), a physical mixture of lidocaine and poly(epsilon-caprolactone) (PM LDC + PCL), and lidocaine (LDC).