Example 46
PCAN component 5a can be synthesized as follows.
Alternatively, cannabidiol can be acylated with succinic anhydride to form the cannabidiol propionic acid derivative shown in the synthesis of Compound 5b, below. Reaction of this intermediate with [62928-11-4] under esterification conditions yields cannabinoid conjugate component 5a.
PCAN component 5b can be synthesized as follows.
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