Xenograft Model for Pancreatic Cancer

Six‐week‐old female NOD‐PrkdcscidIl2rgem1/Smoc mice were purchased from the Shanghai Model Organisms Center, Inc. Samples from patients with PC were cut into small pieces (approximate diameter: 3 mm) and subcutaneously implanted into the axilla of mice. When the tumor volume reached 150 mm³, the mice were administered vehicle or 3 mg/kg AZD5582 by i.v. once a week for 3 weeks, and the tumors and body weights were monitored and measured every 3 days for 3 weeks until euthanasia.
¹⁵ (link) The ethical point was defined as tumor size of approximately 1500 mm³.

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Ma Z., Gu Q., Dai Y., Wang Q., Shi W, & Jiao Z. (2023). Therapeutic potential of SHCBP1 inhibitor AZD5582 in pancreatic cancer treatment. Cancer Science, 115(3), 820-835.

Publication 2023

NOD‐PrkdcscidIl2rgem1/Smoc mice

Corresponding Organization :

Other organizations : Lanzhou University, Lanzhou University Second Hospital

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Variable analysis

independent variables

Administration of vehicle or 3 mg/kg AZD5582 by i.v. once a week for 3 weeks

dependent variables

Tumor volume
Body weight

control variables

Six-week-old female NOD-PrkdcscidIl2rgem1/Smoc mice
Subcutaneous implantation of patient-derived PC samples into the axilla of mice

controls

Positive control: Administration of 3 mg/kg AZD5582
Negative control: Administration of vehicle

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