Details of the RALE score are provided in Figure 2 . To determine the RALE score, each radiograph was divided into quadrants, defined vertically by the vertebral column and horizontally by the first branch of the left main bronchus. Each quadrant was assigned a consolidation score from 0–4 to quantify the extent of alveolar opacities, based on the percentage of the quadrant with opacification and a density score from 1–3 to quantify the overall density of alveolar opacities, unless the consolidation score for that quadrant was 0. The density score (1=hazy, 2=moderate, 3=dense) allows for more quantitative assessment of the density of opacification by quadrant. To calculate the final RALE score, the product of the consolidation and density score for each quadrant were summed for a final RALE score ranging from 0 (no infiltrates) to 48 (dense consolidation in >75% of each quadrant).
In the organ donors, chest radiographs obtained within 24 hours of lung procurement were scored for each donor, using the radiograph obtained closest to the time of procurement. Radiographs were scored by consensus of two physician reviewers without knowledge of clinical data or lung weight. In FACTT, each radiograph was scored independently by two physician reviewers blinded to treatment arm, in order to examine inter-observer reliability.
In the organ donors, chest radiographs obtained within 24 hours of lung procurement were scored for each donor, using the radiograph obtained closest to the time of procurement. Radiographs were scored by consensus of two physician reviewers without knowledge of clinical data or lung weight. In FACTT, each radiograph was scored independently by two physician reviewers blinded to treatment arm, in order to examine inter-observer reliability.
