Obese Pre-Diabetic Asian Indian Cohort

Data and samples from sixty Asian Indian obese pre-diabetic patients were selected from one of the intervention studies of the Madras Diabetes Research Foundation (Chennai, India). They belong to the D-CLIP study (Diabetes Community Lifestyle Improvement Program, Clinicaltrial.gov NCT01283308) [16 (link), 20 (link)] designed to test the effectiveness of stepwise diabetes program [16 (link)]. None of them were on medications at the start of the program. At baseline state, questionnaires permitted to measure habits, quality of life and food frequency of the participants. Anthropometric measurements including height, weight and waist circumstance were obtained using standardized techniques [5 (link)]. For this study, fasting serum samples from 5ml of blood were obtained at basal state, 4 months and one year by standard venepuncture using Vacutainer Plus Plastic Serum and SST Tubes (Becton-Dickinson, Franklin, lakes, NJ). Metabolic parameters were measured as previously detailed [5 (link)]. IL-6, adiponectin, MCP, TNF-alpha, Irisin and BDNF were quantified with ELISA tests [20 (link)]. At baseline, metabolic parameters did not differ significantly between the 2 groups of pre-diabetic individuals, except for the age (S1–S3 Tables).

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Paramasivam P., Meugnier E., Gokulakrishnan K., Ranjini H., Staimez L.R., Weber M.B., Narayan K.M., Vidal H., Tandon N., Prabhakaran D., Mohan A.R., Mohan V., Rome S, & Balasubramanyam M. (2022). Blood-derived miRNA levels are not correlated with metabolic or anthropometric parameters in obese pre-diabetic subjects but with systemic inflammation. PLoS ONE, 17(2), e0263479.

Publication 2022

Vacutainer Plus Plastic Serum and SST Tubes

Adiponectin Asian Clip Diabetes Elisa Food Medications Obese Patients Pre diabetic Serum Tnf alpha Venepuncture

Corresponding Organization : SRM Institute of Science and Technology

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Metabolic parameters (not specified)
Adiponectin
TNF-alpha
Irisin

control variables

Age (as the only variable that differed significantly between the two groups of pre-diabetic individuals at baseline)

controls

Positive controls: None mentioned
Negative controls: None mentioned

Annotations

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