The following variables were analyzed: demographics (age and sex), clinicopathological features (tumor location, tumor size, histological type, and tumor stage), and treatment with chemotherapy. We defined cecum carcinoma, ascending colon cancer, and right-half transverse colon as right-sided CRC, whereas the rest were classified as left-sided CRCs. The well and moderately differentiated adenocarcinomas were histologically categorized as the well-differentiated type, and the poorly differentiated adenocarcinomas included poorly differentiated adenocarcinoma, mucinous adenocarcinoma, signet ring cell cancer, and undifferentiated cancer. Tumor staging was performed according to the 7th edition of the Union for International Cancer Control-American Joint Committee on cancer classification for CRC.
Preoperative blood sampling was performed to measure the neutrophil, lymphocyte, and platelet levels for the calculation of the NLR, PLR, and SII indices. NLR and PLR were defined as the total number of neutrophils or platelets divided by the total number of lymphocytes. SII was calculated with the formula SII = (P × N)/L, where P, N, and L refer to peripheral platelet, neutrophil, and lymphocyte counts, respectively.