Between July 2008 and November 2010, we enrolled heterosexual HIV-1 serodiscordant couples from 9 sites in Kenya and Uganda (Tables S1 and S2).15 (link) HIV-1 seronegative partners had normal renal function, were not infected with hepatitis B virus (HBV), and were not pregnant or breastfeeding. HIV-1 seropositive partners were not using antiretroviral therapy and did not meet Kenyan or Ugandan guidelines for initiation of antiretroviral therapy. The study protocol was approved by the University of Washington Human Subjects Review Committee and ethics review committees at each of the study sites (Table S3). All participants provided written informed consent in English or their local language.
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Baeten J.M., Donnell D., Ndase P., Mugo N.R., Campbell J.D., Wangisi J., Tappero J.W., Bukusi E.A., Cohen C.R., Katabira E., Ronald A., Tumwesigye E., Were E., Fife K.H., Kiarie J., Farquhar C., John-Stewart G., Kakia A., Odoyo J., Mucunguzi A., Nakku-Joloba E., Twesigye R., Ngure K., Apaka C., Tamooh H., Gabona F., Mujugira A., Panteleeff D., Thomas K.K., Kidoguchi L., Krows M., Revall J., Morrison S., Haugen H., Emmanuel-Ogier M., Ondrejcek L., Coombs R.W., Frenkel L., Hendrix C., Bumpus N.N., Bangsberg D., Haberer J.E., Stevens W.S., Lingappa J.R, & Celum C. (2012). Antiretroviral Prophylaxis for HIV-1 Prevention among Heterosexual Men and Women. The New England journal of medicine, 367(5), 399-410.
Publication 2012
Hepatitis b virus Heterosexual Hiv 1 Hiv seropositive Renal Therapy
Corresponding Organization :
Other organizations :
Fred Hutch Cancer Center, University of Washington, Kenyatta National Hospital, University of Nairobi, Centers for Disease Control and Prevention, The AIDS Support Organization, Kenya Medical Research Institute, University of California, San Francisco, Makerere University, University of Manitoba, Moi University, Indiana University – Purdue University Indianapolis, Pediatrics and Genetics, Seattle Children's Hospital, Johns Hopkins University, Massachusetts General Hospital, Harvard University
HIV-1 seronegative partners had normal renal function
HIV-1 seronegative partners were not infected with hepatitis B virus (HBV)
HIV-1 seronegative partners were not pregnant or breastfeeding
HIV-1 seropositive partners were not using antiretroviral therapy
HIV-1 seropositive partners did not meet Kenyan or Ugandan guidelines for initiation of antiretroviral therapy
positive controls
None explicitly mentioned
negative controls
None explicitly mentioned
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