All patients with a reproductive disorder undergo regular cardiovascular screening at a specialized vascular outpatient clinic in one of the participating hospitals as part of standard care for cardiovascular diseases. The study population consists of women aged 45-55 years within three different groups:

Women with PCOS defined by Rotterdam consensus criteria, requiring the presence of at least two of the following criteria: (i) oligo−/anovulation, (ii) clinical and/or biochemical hyperandrogenism, and (iii) polycystic ovaries on ultrasonography.

Women with POI defined as women with secondary amenorrhea for at least 4 months accompanied by elevated FSH levels above 40 IU/L, occurring prior to 40 years of age.

Women with a history of HPD (PIH, early-onset PE (i.e. delivery before 34 weeks of gestation) and late-onset PE (i.e. delivery after 34 weeks of gestation)) according to the ISSHP criteria, verified in clinical records.

Patients with any serious illness that can compromise study participation, patients with high risk for contrast nephropathy (renal dysfunction with an estimated glomerular filtration rate < 60 ml/min/1.73 m2) or patients with a history of myocardial infarction are excluded from the study.
After written informed consent is obtained, patients will undergo cardiovascular imaging assessment by CCT imaging, biomarkers and a non-invasive vascular measurement.
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