At 15 d after the inoculation of UMUC3 BCa cells, mice (3 per group) were either intravenously administered 18F-labeled galactodendritic unit 4 (2.9–3.3 MBq) or intravesically administered (i.e., instillation directly into the bladder via insertion of an urethral catheter) 14.7–15.3 MBq of 18F-galactodendritic unit 4 or 18F-FDG.
At 0.5, 1, and 2 h after intravenous administration of 18F-labeled galactodendritic unit4, PET images were recorded on an Inveon PET/CT scanner (Siemens).
At 30 min after intravesical administration, the mice were anesthetized with 1.5%–2% isoflurane, the bladder was fully emptied and flushed with PBS, and PET images were recorded (following previously reported methodology (21 (link))) at 1 h after intravesical administration. All images were visualized in AMIDE software (version 1.0.4;http://amide.sourceforge.net ).
Acute biodistribution studies were performed at 2 h after intravenous injection of 18F-galactodendritic unit4 (21 (link)), and the radioactivity associated with each organ was expressed as a percentage of injected dose per gram of organ.
At 0.5, 1, and 2 h after intravenous administration of 18F-labeled galactodendritic unit
At 30 min after intravesical administration, the mice were anesthetized with 1.5%–2% isoflurane, the bladder was fully emptied and flushed with PBS, and PET images were recorded (following previously reported methodology (21 (link))) at 1 h after intravesical administration. All images were visualized in AMIDE software (version 1.0.4;
Acute biodistribution studies were performed at 2 h after intravenous injection of 18F-galactodendritic unit
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