Ion mobility experiments were performed using the first ion level (~10.8 m separation length) of a multilevel SLIM system described previously.16 (link) Briefly, ions generated via ESI enter the vacuum system through a heated multi-inlet capillary (5 × 250 μm) and traverse a high pressure S-shaped ion funnel (1st vacuum stage) and a slanted ion funnel (2nd vacuum stage) before entering the SLIM (3.50 Torr helium buffer gas). The dimensions and operating conditions of the multilevel SLIM have been previously described.16 (link) Ions exiting the SLIM are collected by a rectangular ion funnel and transferred through a segmented quadruple prior to entering an Agilent 6230 TOF-MS.
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Multilevel SLIM System for Ion Mobility
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Corresponding Organization : Pacific Northwest National Laboratory
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Variable analysis
independent variables
- Separation length of SLIM system
- Ion mobility/separation of analytes
- Heated multi-inlet capillary dimensions (5 × 250 μm)
- High pressure S-shaped ion funnel (1st vacuum stage)
- Slanted ion funnel (2nd vacuum stage)
- SLIM dimensions and operating conditions
- Helium buffer gas pressure (3.50 Torr)
- Rectangular ion funnel and segmented quadrupole before TOF-MS
- Positive control: Not mentioned
- Negative control: Not mentioned
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