TACE Protocol for Hepatic Tumor Treatment

TACE was performed according to our institutional standard protocol and has been previously reported (30 (link), 31 (link)). All operators had at least eight years of experience in performing TACE procedures. TACE was performed using transfemoral arterial access route with a micro-puncture system by placing a 5F vascular introducer (Cook, Bloomington, Indiana, USA) and celiac or superior mesenteric arteriography was carried out to assess the arterial anatomy, tumor supplying vessel and patency of the portal vein. A 2.6-Fr microcatheter (Terumo, Japan) was inserted into the tumor donor arteries as superselectively as possible to identify the staining and arteries feeding the target lesions. First, an emulsion of 5-20 mL lipiodol (Lipiodol Ultrafluido, Guerbet, France) mixed with 20-60 mg doxorubicin hydrochloride (Hisun Pharmaceutical Co. Ltd., Zhejiang, China) was injected into tumor feeding branch of the hepatic artery. Then the gelatin sponge particles (300–500 um, Cook, Bloomington, Indiana, USA) mixed with contrast material were administered into the tumor-feeding arteries until stasis of the arterial flow was achieved.

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Yan L., Ren Y., Qian K., Kan X., Zhang H., Chen L., Liang B, & Zheng C. (2021). Superselective Transarterial Chemoembolization for Unresectable or “Ablation Unsuitable” Hepatocellular Carcinoma in the Caudate Lobe: A Real World, Single-Center Retrospective Study. Frontiers in Oncology, 11, 678847.

Publication 2021

5F vascular introducer 2.6-Fr microcatheter Lipiodol Ultrafluido gelatin sponge particles

Arterial Arteriography Contrast material Donor Doxorubicin hydrochloride Emulsion Gelatin Hepatic artery Hepatic tumor Lipiodol Mesenteric Pharmaceutical Portal vein Puncture Sponge Tace Tumor Vessel

Corresponding Organization : Huazhong University of Science and Technology

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Variable analysis

independent variables

Transfemoral arterial access route with a micro-puncture system by placing a 5F vascular introducer
Celiac or superior mesenteric arteriography to assess the arterial anatomy, tumor supplying vessel and patency of the portal vein
Insertion of a 2.6-Fr microcatheter into the tumor donor arteries as superselectively as possible
Injection of an emulsion of 5-20 mL lipiodol mixed with 20-60 mg doxorubicin hydrochloride into the tumor feeding branch of the hepatic artery
Administration of gelatin sponge particles (300–500 um) mixed with contrast material into the tumor-feeding arteries until stasis of the arterial flow was achieved

dependent variables

Not explicitly mentioned

control variables

All operators had at least eight years of experience in performing TACE procedures

controls

No positive or negative controls were explicitly mentioned.

Annotations

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