Automated Brain MRI Segmentation Protocol

Brain MRI data were acquired with a 1.5-Tesla scanner (GE Healthcare, Milwaukee, Wisconsin) using an eight-channel head coil during a 30-min brain imaging protocol that was previously described in detail (Ikram et al. 2011 (link); Jones et al. 1999 (link)). Two trained technicians performed all examinations in a standardized way. This protocol included high-resolution axial fluid-attenuated inversion recovery (FLAIR), T1-weighted, and T2-weighted sequences. The T1-weighted image was used for amygdala segmentation and consisted of a 3D spoiled gradient-recalled echo (SPGR) scan, with voxel volume of 0.49 × 0.49 × 0.80 mm³. Automatic segmentation of subcortical brain structures, including the amygdala and hippocampus left and right, was performed on T1-weighted images using Freesurfer software (version 4.5.0) (FreeSurfer 2013 ). This rendered volumetric measures of gray matter (in mm³). Exact processing details are described elsewhere (Reuter et al. 2012 (link); Desikan et al. 2006 (link); Fischl et al. 2002 (link)).

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Gotink R.A., Vernooij M.W., Ikram M.A., Niessen W.J., Krestin G.P., Hofman A., Tiemeier H, & Hunink M.G. (2018). Meditation and yoga practice are associated with smaller right amygdala volume: the Rotterdam study. Brain Imaging and Behavior, 12(6), 1631-1639.

Publication 2018

1.5-Tesla scanner eight-channel head coil

Amygdala Brain structures Echo Examinations Gray matter Head Hippocampus Inversion Scan

Corresponding Organization :

Other organizations : Erasmus MC

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Volumetric measures of gray matter (in mm^3) for the amygdala and hippocampus (left and right)

control variables

Brain imaging protocol with high-resolution axial fluid-attenuated inversion recovery (FLAIR), T1-weighted, and T2-weighted sequences
1.5-Tesla scanner (GE Healthcare, Milwaukee, Wisconsin) with an eight-channel head coil
Standardized examinations performed by two trained technicians
Automatic segmentation of subcortical brain structures using Freesurfer software (version 4.5.0)

controls

No positive or negative controls were explicitly mentioned in the provided information.

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