The intrinsic clearance of UK4b in liver microsomes (human) was determined by Eurofins Panlabs (St. Charles, MO) through their standard protocol, including measurements at five time-points (0, 15, 30, 45, and 60 min) in order to estimate the intrinsic clearance (CLint) and half-life (t1/2). The inhibitory activity of UK4b at 10 μM against potassium channel hERG was tested by Eurofins Cerep (France) using the standard Cerep protocol.
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