5% Benzoyl Peroxide Topical Composition

Example 7

A composition comprising 5% Benzoyl peroxide (BPO) as active ingredient:

The process for the preparation of the compositions listed above was as follows:

• • 1. Disodium EDTA and Carbomer were added to the water and homogenized;
  • 2. Glycerin was added to stage 1 and the mixture was stirred;
  • 3. PED-40 hydrogenated castor oil was heated to 40° C. separately and after clear liquid was obtained, it was added to stage 2;
  • 4. 20% solution of sodium hydroxide was added for neutralization;
  • 5. A solution of imidazolidinyl urea in water was added to stage 4;
  • 6. Benzoyl peroxide was added to ethoxydiglycol separately and passed through Fryma colloid mill, twice;
  • 7. Silica microspheres were added to the stage 6 and resultant mixture was stirred;
  • 8. Stage 7 was added to stage 5 and the mixture was homogenized.