In Vivo Animal Study Protocol

These assays
were performed according to the previously reported procedures.^{21 (link)} All the in vivo studies were performed under
an animal protocol (PRO00005315) approved by the University Committee
on Use and Care of Animals of the University of Michigan, in accordance
with the recommendations in the Guide for the Care and Use of Laboratory
Animals of the National Institutes of Health.

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Aguilar A., Lu J., Liu L., Du D., Bernard D., McEachern D., Przybranowski S., Li X., Luo R., Wen B., Sun D., Wang H., Wen J., Wang G., Zhai Y., Guo M., Yang D, & Wang S. (2017). Discovery of 4-((3′R,4′S,5′R)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development. Journal of Medicinal Chemistry, 60(7), 2819-2839.

Publication 2017

Animals

Corresponding Organization :

Other organizations : University of Michigan–Ann Arbor, Sun Yat-sen University Cancer Center, Sun Yat-sen University

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Protocol cited in 3 other protocols

Variable analysis

independent variables

Not explicitly mentioned

dependent variables

Not explicitly mentioned

control variables

Kept constant to ensure valid results. The in vivo studies were performed under an animal protocol (PRO00005315) approved by the University Committee on Use and Care of Animals of the University of Michigan, in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health.

controls

No positive or negative controls were explicitly mentioned.

Annotations

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