High-resolution 7T MRI of Mouse Brains
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Corresponding Organization :
Other organizations : University of Toronto, Centre for Addiction and Mental Health, Hospital for Sick Children, National Human Genome Research Institute, National Institutes of Health, Montreal Neurological Institute and Hospital
Protocol cited in 6 other protocols
Variable analysis
- Gadolinium enhancement to increase contrast in the image
- T2-weighted MRI data from 25 C57Bl/6 fixed mouse brains
- Proton-free susceptibility-matching fluid (Fluorinert FC-77, 3M Corp., St. Paul, MN) used to fill the 13-mm-diameter plastic tubes containing the samples
- Custom-built, 14-mm-diameter solenoid coils with a length of 18.3 mm and over wound ends used to image three brains in parallel
- Imaging parameters: T2-weighted, 3D fast spin-echo sequence, with TR/TE = 325/32 ms, four averages, field-of-view 14 × 14 × 25 mm^3 and matrix size = 432 × 432 × 780 giving an image with 32 μm isotropic voxels
- Geometric distortion due to position of the three coils inside the magnet was corrected using an MR phantom
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