PET/CT Imaging of COVID-19 Patients

Patients were asked to fast for a minimum of six hours prior to PET/CT scans. PET/CT imaging was conducted via a 112-ring digital light guide PET/CT (uMI780, United Imaging, China) according to published guidelines for PET/CT imaging 12 (link). Helical CT was implemented from the head to proximal thigh prior to PET procurement based on the standardized protocol. Static acquisitions from head to proximal thigh were obtained 45 minutes post ¹⁸F-FDG injection and lasted for a period of 15 minutes. Dynamic acquisitions were done as follows: imaging started at the time of injection of ¹⁸F-FDG (3.75 MBq/kg produced from Guangzhou Atom High Tech Radiopharmaceutical Co.,Ltd., Guandong Province, China) and continued for 60 minutes. Dynamic scans were conducted from the lung apex to the liver for the COVID-19 group and control group 2. Each dynamic PET study lasted 60 minutes that contained 48 frames (time × frame: 5s × 18, 10s × 6, 30s × 5, 60s × 5, 150s × 8, 300s × 6) and was adjusted for isotope decay, scattering events, and random coincidence.

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Yao J., Liu J., Bi L., Huang Y., Wang L., Zhang F., Wang Y, & Jin H. (2022). The imaging quantification of multiple organs by dynamic 18F-FDG PET/CT in discharged COVID-19 patients: A prospective pilot study. International Journal of Medical Sciences, 19(10), 1539-1547.

Publication 2022

uMI780

18f fdg Covid 19 Ct 112 Frame Head Helical ct Isotope Light Liver group Lung Patients Pet ct Radiopharmaceutical Ring digital Scans Thigh

Corresponding Organization : Sun Yat-sen University

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Variable analysis

independent variables

Fasting duration (minimum of six hours prior to PET/CT scans)

dependent variables

PET/CT imaging results
Dynamic acquisitions (from the lung apex to the liver for the COVID-19 group and control group 2)

control variables

Published guidelines for PET/CT imaging
Helical CT implementation from the head to proximal thigh prior to PET procurement based on the standardized protocol
Static acquisitions from head to proximal thigh obtained 45 minutes post 18F-FDG injection and lasting for 15 minutes
Dynamic acquisitions lasting 60 minutes with 48 frames (time × frame: 5s × 18, 10s × 6, 30s × 5, 60s × 5, 150s × 8, 300s × 6) and adjusted for isotope decay, scattering events, and random coincidence

controls

Positive control: Not specified
Negative control: Control group 2

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