Tretinoin-Based Topical Gel Formulation

Example 4

A composition comprising Tretinoin as active ingredient:

The process for the preparation of the composition was as follows:

• • 1. CMC Na (carboxymethyl cellulose sodium) and Natrosol (HEC) were dispersed in water until a clear gel was formed
  • 2. Glycerin and benzyl alcohol were added to stage 1 and mixed;
  • 3. Oleic acid, isopropanol, BHT, sorbic acid, Poloxamer 407 and tretinoin were heated to 50° C. while stirring until clear solution was obtained. Then the solution was cooled to the room temperature;
  • 4. Silica Microspheres were added to the cooled oily phase and resultant mixture was stirred for at least one hour;
  • 5. Stage 4 was added to the stage 2 and stirred for one hour under vacuum.

An opaque yellowish gel was obtained.