The tumor size was measured via PET/CT measurements on a small animal PET/CT scanner (Inveon PET/CT, Siemens Medical Solutions, Knoxville, TN, USA) in accordance to a standard protocol as described before.25 (link) Mice were anesthetized using isoflurane and received FDG intravenously. Evaluation of the images was performed as described before.8 (link) Treatment outcome determined according to clinical staging as follows: (I) progressive disease (PD) = tumor volume >25% vs. baseline (= day 0); (II) stable disease (SD): tumor volume similar to initial staging (≤25% vs. day 0); (III) partial response (PR): tumor volume 50% lower or more vs. baseline (=day 0). Follow-up was done at day 30 (= short-term) and, in some cases, at ~day 50 (= long-term follow-up).
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Small Animal PET/CT Tumor Measurement
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Corresponding Organization : University of Rostock
Other organizations : Universitätsmedizin Greifswald
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Variable analysis
independent variables
- Tumor size measurement via PET/CT
- Treatment outcome (progressive disease, stable disease, partial response)
- Isoflurane anesthesia
- FDG administration
- Baseline tumor volume (day 0) as a reference for treatment outcome
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