Exosomes were fluorescently labeled using PKH67 membrane dye (Sigma). Then, the exosomes were cocultured with fibroblasts for 24 h. Nuclei were stained with Hoechst33342 for seconds, and the coverslips were sealed with resistant fluorescence quenching liquid. The fluorescence signals were analyzed by Leica SP5 confocal laser scanning microscope (Leica Microsystems, Wetzlar, Germany).
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