In Vivo Magnetic Resonance Imaging of Arterial Nanoparticles

All MR images were acquired on a 9.4 T 31 cm MRI scanner (Agilent Technologies) with software designed for pre-clinical MR imaging research (Vnmrj, Agilent Technologies). A custom three-loop volume coil was used. Both 3D multi-band SWIFT (MB-SWIFT) and 3D gradient echo (GRE) images were acquired (25 (link)). MR imaging was performed at 4 h and 24 h after loading and then unloading msIONPs from the lumen of an artery. The detailed methods are given in the Supplementary Materials and closely follow previous protocols (25 (link)).

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Manuchehrabadi N., Gao Z., Zhang J., Ring H.L., Shao Q., Liu F., McDermott M., Fok A., Rabin Y., Brockbank K.G., Garwood M., Haynes C.L, & Bischof J.C. (2017). Improved Tissue Cryopreservation using Inductive Heating of Magnetic Nanoparticles. Science translational medicine, 9(379), eaah4586.

Publication 2017

Vnmrj

Artery Echo

Corresponding Organization : University of Minnesota

Other organizations : Carnegie Mellon University, Clemson University

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Variable analysis

independent variables

Time of MR imaging (4 h and 24 h after loading and unloading msIONPs)

dependent variables

MR images acquired using 3D multi-band SWIFT (MB-SWIFT) and 3D gradient echo (GRE) techniques

control variables

All MR images were acquired on a 9.4 T 31 cm MRI scanner (Agilent Technologies) with software designed for pre-clinical MR imaging research (Vnmrj, Agilent Technologies)
A custom three-loop volume coil was used

controls

The detailed methods are given in the Supplementary Materials and closely follow previous protocols (25 (link))

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