Production and Characterization of 89Zr

⁸⁹Zr was produced at Memorial Sloan Kettering Cancer Center (MSKCC) on a TR19/9 cyclotron (Ebco Industries Inc.) via the ⁸⁹Y(p,n)⁸⁹Zr reaction, and purified to yield ⁸⁹Zr with a specific activity of 5.28-13.43 mCi/μg (470-1195 Ci/mmol) of zirconium (33 (link)). Activity measurements were performed using a CRC-15R Dose Calibrator (Capintec). For the quantification of activities, experimental samples were counted on an Automatic Wizard (33 (link)) γ-Counter (PerkinElmer). All in vivo experiments were performed according to protocols approved by the MSKCC Institutional Animal Care and Use Committee. A purity of greater than 95% was confirmed using radio-TLC for all of the ⁸⁹Zr-labeled DFO-Dox-C’ dots.

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Aragon-Sanabria V., Aditya A., Zhang L., Chen F., Yoo B., Cao T., Madajewski B., Lee R., Turker M.Z., Ma K., Monette S., Chen P., Wu J., Ruan S., Overholtzer M., Zanzonico P., Rudin C.M., Brennan C., Wiesner U, & Bradbury M.S. (2022). Ultrasmall Nanoparticle Delivery of Doxorubicin Improves Therapeutic Index for High-Grade Glioma. Clinical Cancer Research, 28(13), 2938-2952.

Publication 2022

CRC-15R Dose Calibrator γ-Counter

Cancer Cyclotron Ebco Institutional animal care and use committee Zirconium

Corresponding Organization : Kettering University

Other organizations : Hunter College

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Variable analysis

independent variables

Production of ⁸⁹Zr on a TR19/9 cyclotron (Ebco Industries Inc.) via the ⁸⁹Y(p,n)⁸⁹Zr reaction

dependent variables

Specific activity of ⁸⁹Zr (5.28-13.43 mCi/μg or 470-1195 Ci/mmol)
Purity of ⁸⁹Zr-labeled DFO-Dox-C' dots (greater than 95%)

control variables

Activity measurements performed using a CRC-15R Dose Calibrator (Capintec)
Quantification of activities using an Automatic Wizard (33 (link)) γ-Counter (PerkinElmer)
All in vivo experiments performed according to protocols approved by the MSKCC Institutional Animal Care and Use Committee

controls

Positive control: Not explicitly mentioned
Negative control: Not explicitly mentioned

Annotations

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