The study was a parallel-groups, placebo-controlled trial of topiramate in heavy drinkers, all of whom received medical management (20 ), a brief psychosocial intervention, at each of 9 treatment visits. Patients were randomly assigned to treatment group and double-blind conditions were maintained throughout the study. Raters were trained in the reliable use of all assessments. The study was conducted in three phases: a one-week pre-treatment assessment period, a 12-week treatment period, and a 9-day medication taper period.
Protocol detail
Topiramate for Heavy Drinking Treatment
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Corresponding Organization : Quinnipiac University
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Variable analysis
independent variables
- Treatment group assignment (topiramate vs. placebo)
- Drinking outcomes (unspecified)
- Medical management (a brief psychosocial intervention) provided to all participants at each of the 9 treatment visits
- Double-blind conditions maintained throughout the study
- Raters trained in the reliable use of all assessments
- Placebo control group
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