Bovine incisors were embedded in self-curing acrylic resin (Paladur, Germany) leaving the frontal enamel free of resin. Specimens were cut in half, and its lateral surface was polished down to 1 µm particle size. Then, teeth were treated with 0.1 mL of each treatment 3 times per day for 5 days (Table 1 , Fig. S2.A ). Since MOFs’ treatments are the only ones which are in powder, 1 mg of each MOF formulation was mixed with 15 µL of HEPES buffer and, then, was applied over the teeth. The complete description of this tooth sample preparation can be found in the ESM.
List with the different treatments applied over the dental samples
| Treatments’ list |
|---|
| Control (HEPES buffer) |
| Cannabidiol (10 mg/mL) |
| Olivetol (10 mg/mL) |
| DPPC liposomes |
| DPPC liposomes loaded with olivetol |
| γ-CD-MOFs KCl loaded with olivetol |
| γ-CD-MOFs KNO3 loaded with olivetol |
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