Dynamic PiB PET Imaging Protocol

Dynamic ¹¹C-labeled Pittsburgh compound B (PiB) PET scans were obtained on a GE Advance PET scanner in 3D mode, acquired over 70 minutes immediately following an intravenous bolus injection of ¹¹C-PiB. The PiB PET scans were processed using a method described in detail previously (Bilgel et al., 2018 (link); Walker et al., 2020 (link)). Briefly, the anatomical label image was transformed from MRI to PET space and the PET PiB distribution volume ratio (DVR) image was generated using cerebellar gray matter as the reference region. Mean cortical DVR (cDVR) was calculated by averaging DVR values across cortical regions, using parcellation maps generated by MRICloud (Walker et al., 2020 (link)). PiB positivity was defined as a mean cDVR threshold of 1.06 based on two-class Gaussian mixture modeling (Bilgel et al., 2016 (link)).

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Pettigrew C., Soldan A., Brichko R., Zhu Y., Wang M.C., Kutten K., Bilgel M., Mori S., Miller M.I, & Albert M. (2021). Computerized paired associate learning performance and imaging biomarkers in older adults without dementia. Brain imaging and behavior, 16(2), 921-929.

Publication 2021

Advance PET scanner

11c pib Cerebellar gray matter Cortical Maps Pet scans Walker

Corresponding Organization : Johns Hopkins University

Other organizations : National Institute on Aging

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Variable analysis

independent variables

Intravenous bolus injection of ^11C-PiB

dependent variables

Cortical distribution volume ratio (cDVR) of ^11C-PiB

control variables

Cerebellar gray matter as the reference region for PET PiB distribution volume ratio (DVR) image generation
MRI-based anatomical label image transformed to PET space

controls

Positive control: Not explicitly mentioned.
Negative control: Not explicitly mentioned.

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