Robust Gene Expression Analysis in Medulloblastoma

The gene expression analysis shown for candidate genes in medulloblastoma, other tumours and normal tissues was compiled from multiple gene expression profiling studies [5 (link),39 (link)–47 (link)] (Kool et al. unpublished data). All samples were analysed using the Affymetrix GeneChip Human Genome U133 Plus 2.0 arrays. The MAS5.0 algorithm of the GCOS program (Affymetrix Inc.) was used to normalize the expression data. Data were analysed and statistically verified using the R2 software platform for analysis and graphic visualization of microarray data (see http://r2.amc.nl).

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Vaillant C., Valdivieso P., Nuciforo S., Kool M., Schwarzentruber-Schauerte A., Méreau H., Cabuy E., Lobrinus J.A., Pfister S., Zuniga A., Frank S, & Zeller R. (2015). Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma. PLoS ONE, 10(4), e0124870.

Publication 2015

GeneChip Human Genome U133 Plus 2.0 arrays MAS5.0 algorithm

Gene expression analysis Genechip Genes Human genome Medulloblastoma Microarray Normal tissues Tumours

Corresponding Organization :

Other organizations : University of Basel, German Cancer Research Center, Friedrich Miescher Institute, University Hospital of Geneva

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The gene expression analysis shown for candidate genes in medulloblastoma, other tumours and normal tissues was compiled from multiple gene expression profiling studies [5 (link),39 (link)–47 (link)] (Kool et al. unpublished data). All samples were analysed using the Affymetrix GeneChip Human Genome U133 Plus 2.0 arrays.
The MAS5.0 algorithm of the GCOS program (Affymetrix Inc.) was used to normalize the expression data.
Data were analysed and statistically verified using the R2 software platform for analysis and graphic visualization of microarray data (see http://r2.amc.nl).

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