Participants underwent CT on a multidetector CT (MDCT) scanner (Somatom Sensation 4, Siemens Medical Systems, Erlangen, Germany) [18 (link),19 (link)]. Thoracic CT imaging was obtained to assess coronary calcification (140 kVp, a reference exposure of 50 mAs, in-plane pixel size 0. 68 × 0.68 mm and slice thickness 2.5 mm, field of view (FOV): 35 cm) and included approximately vertebral levels T6–T10. The lumbar spine CT included vertebral levels L1–L2 (120 kVp, a reference exposure of 150 mAs, in-plane pixel size of 0.98 by 0.98 and slice thickness of 1.0 mm, FOV: 50 cm). In addition, lateral scout images were acquired, covering levels T6–L5. The scans were performed at the same visit and each subject was scanned with two hydroxyapatite phantoms (Image Analysis, Inc., Lexington, KY, USA), one placed in the lumbar region and the second one in the thorax region, to enable the scan data to be calibrated into equivalent mineral density (mg/cm3 of hydroxyapatite).
Protocol detail
Coronary and Lumbar Spine CT Imaging
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Calcification
Coronary
Ct scanner
Hydroxyapatite
Lumbar region
Lumbar spine
Mineral
Multidetector ct
Scan
Thorax
Vertebral
Corresponding Organization : Beth Israel Deaconess Medical Center
Other organizations : O.N. Diagnostics (United States), University of California, Berkeley, Icelandic Heart Association, Harvard University
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Variable analysis
independent variables
- None explicitly mentioned
- Coronary calcification
- Equivalent mineral density (mg/cm^3 of hydroxyapatite)
- Type of MDCT scanner (Somatom Sensation 4, Siemens Medical Systems, Erlangen, Germany)
- CT imaging parameters for thoracic scan (140 kVp, 50 mAs, in-plane pixel size 0.68 x 0.68 mm, slice thickness 2.5 mm, FOV: 35 cm)
- CT imaging parameters for lumbar scan (120 kVp, 150 mAs, in-plane pixel size 0.98 x 0.98 mm, slice thickness 1.0 mm, FOV: 50 cm)
- Hydroxyapatite phantoms (one placed in the lumbar region and the second one in the thorax region) to enable scan data calibration
- Positive control: Hydroxyapatite phantoms placed in the lumbar and thorax regions to enable scan data calibration
- Negative control: Not explicitly mentioned
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