A two-channel head mount was implanted on the skull of PV::CrTfl+/y (n = 18) and 18 PV::CrTfl−/y (n = 18) mice, at least two days after IOS imaging. EEG was recorded using a preamplifier connected to a data acquisition system and Sirenia Software 1.7.9 (Pinnacle Technology). We evaluated spontaneous (baseline) cortical activity for 24 h, before assessing the effects of kainic acid (KA; intraperitoneal injection, 10 mg/kg). To quantify seizure episodes, we used Sirenia Seizure Pro 1.8.4 [29 (link)]. A two-tailed t-test and χ2 test were used to assess differences between groups.
Corresponding Organization : Fondazione Stella Maris
Other organizations :
National Research Council, Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas, University of Florence, Scuola Normale Superiore, University of California, Irvine
Head mount implantation on the skull (at least two days after IOS imaging)
EEG recording using a preamplifier connected to a data acquisition system and Sirenia Software 1.7.9
Quantification of seizure episodes using Sirenia Seizure Pro 1.8.4
controls
Positive control: Not explicitly mentioned
Negative control: Not explicitly mentioned
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