Pharmacological Modulation of rVLM in Hypertension

(1) SCH 58261 (an A_2AR antagonist) was microinjected into the rVLM of EA-treated DSHRs (n = 9). The vehicle (DMSO) was administered into other sites of the rVLM in random order in five of these nine animals. (2) The rVLM of DSHRs treated with sham-EA (n = 9) was administered with CGS-21680 (an A_2AR agonist). The vehicle (DMSO) was randomly microinjected into the different rVLM sites in five of the nine rats. (3) In separate rats in normotensive groups, SCH 58261 and its vehicle (n = 4) or CGS-21680 and its vehicle (n = 4) were microinjected into different sites of the rVLM in random order.

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Guo Z.L., Tjen-A-Looi S.C., Nguyen A.T., Fu L.W., Su H.F., Gong Y.D, & Malik S. (2023). Adenosine A2A receptors in the rostral ventrolateral medulla participate in blood pressure decrease with electroacupuncture in hypertensive rats. Frontiers in Cardiovascular Medicine, 10, 1275952.

Publication 2023

Animals Cgs 21680 Dmso Rats Sch 58261

Corresponding Organization :

Other organizations : University of California, Irvine

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Variable analysis

independent variables

Microinjection of SCH 58261 (an A2AR antagonist) into the rVLM of EA-treated DSHRs
Microinjection of the vehicle (DMSO) into different sites of the rVLM in EA-treated DSHRs
Microinjection of CGS-21680 (an A2AR agonist) into the rVLM of sham-EA treated DSHRs
Microinjection of the vehicle (DMSO) into different sites of the rVLM in sham-EA treated DSHRs
Microinjection of SCH 58261 and its vehicle into different sites of the rVLM in normotensive rats
Microinjection of CGS-21680 and its vehicle into different sites of the rVLM in normotensive rats

dependent variables

Not explicitly mentioned

control variables

Microinjection sites in the rVLM (randomized)

positive controls

Microinjection of SCH 58261 and its vehicle into the rVLM of normotensive rats
Microinjection of CGS-21680 and its vehicle into the rVLM of normotensive rats

negative controls

Microinjection of the vehicle (DMSO) into different sites of the rVLM in EA-treated DSHRs
Microinjection of the vehicle (DMSO) into different sites of the rVLM in sham-EA treated DSHRs

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