MRI data were acquired in a group of 66 healthy subjects (31 males, 35 females, median age = 36.7 years, range = 23.0-81.6 years, all right-handed). We tested for linear and nonlinear relationships between brain structure and age (see below) and also performed subgroup analyses for which we divided subjects into young adults (YA) (n = 37, 16 males, 21 females, median age = 29.1, range = 23.0-40.2 years), middle-aged adults (MA) (n = 19, 9 males, 10 females, median age = 48.0, range = 41.0-59.6 years) and older adults (OA) (n = 10, 6 males, 4 females, median age = 67.9, range = 60.0-81.6 years). The ages chosen for defining the different age subgroups are broadly consistent with previous studies in YA (Giorgio et al., 2008; McLaughlin et al., 2007; O'Sullivan et al., 2001; Pfefferbaum et al., 2005; Sullivan et al., 2006 ), MA (Salat et al., 2005a,b ) and OA (McLaughlin et al., 2007; Salat et al., 2005b ).
None of the participants had a history of psychiatric or neurological disease or substance abuse. On MRI they did not show overt abnormalities such as infarct, vascular malformation or tumour and none of them had WM lesions. Informed written consent was obtained from all participants according to ethical approval from the Oxfordshire Research Ethics Committee C.
None of the participants had a history of psychiatric or neurological disease or substance abuse. On MRI they did not show overt abnormalities such as infarct, vascular malformation or tumour and none of them had WM lesions. Informed written consent was obtained from all participants according to ethical approval from the Oxfordshire Research Ethics Committee C.
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