Measuring Visual Acuity in Mice

The OKR was used to approximate the visual function of mice. OptoMotry software and an apparatus (Cerebral Mechanics Inc., Medicine Hat, AB, Canada) were used to measure the OKR as before [6 (link)]. Mice were unrestrained on a platform in a closed dark chamber containing four screens and a camera used to detect if mice track a 100% contrast grating with varying spatial frequency starting at 0.042 cycles/degree. Data are presented as cycles/degree.

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Shamsher E., Khan R.S., Davis B.M., Dine K., Luong V., Cordeiro M.F, & Shindler K.S. (2024). Intranasal Resveratrol Nanoparticles Enhance Neuroprotection in a Model of Multiple Sclerosis. International Journal of Molecular Sciences, 25(7), 4047.

Publication 2024

OptoMotry software

Corresponding Organization : Western Eye Hospital

Other organizations : Hôpital Ophtalmique Jules-Gonin

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Variable analysis

independent variables

Spatial frequency of the grating stimulus

dependent variables

Optokinetic reflex (OKR) performance

control variables

Contrast of the grating stimulus (100%)
Platform with mice unrestrained in a closed dark chamber
Four screens and a camera to detect mouse tracking

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