Synthesis of Phenylacetamide Derivatives

To a solution of 1 mmol aniline/benzylamine derivatives in 4 ml DMF, 1 mmol chloroacetylchloride was added at 0 °C. The mixture was stirred at room temperature for 5 h and poured into water and then filtered to get phenylacetamide derivatives. The obtained solids were then filtered, dried, and recrystallized from ethanol.

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Khaleghi N., Esmkhani M., Noori M., Dastyafteh N., Ghomi M.K., Mahdavi M., Sayahi M.H, & Javanshir S. (2024). Copper supported modified magnetic carrageenan as a bio-based catalyst for the synthesis of novel scaffolds bearing the 1,2,3-triazole unit through the click reaction. Nanoscale Advances, 6(9), 2337-2349.

Publication 2024

Corresponding Organization :

Other organizations : Tehran University of Medical Sciences, Iran University of Science and Technology, Payame Noor University

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Variable analysis

independent variables

Amount of chloroacetylchloride added (1 mmol)

dependent variables

Yield of phenylacetamide derivatives

control variables

Amount of aniline/benzylamine derivatives (1 mmol)
Volume of DMF (4 ml)
Reaction temperature (0 °C for addition, then room temperature)
Reaction time (5 hours)

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