Comprehensive TLR Family Alignments

The LRRs alignments within the TLR family were made for TLR1 from four species (human [Q15399, Q5FWG5, Q6FI64, Q32MK3], mouse [Q9EPQ1], pig [Q4LDR7, Q59HI9], Takifugu rubripes [Q5H727]); TLR2 from 17 species (human [O60603], mouse [Q9QUN7, Q8K3D9, Q811T5], pig [Q59HI8, Q5DX20, Q76L24], chicken [Q9DD78 (TLR2.1), Q9DGB6 (TLR2.2)], bovine [Q95LA9], rat [Q6YGU2], dog [Q689D1], rabbit [AAM50059], goat [ABI31733], horse [AAR08196], hamster [Q9R1F8], Cynomolgus monkey [Q95M53], domestic water buffalo [Q2PZH4], Nilgai [Q2V897], Takifugu rubripes [Q5H725], zebrafish [Q6TS42], Japanese flounder [Q76CT8]); TLR3 from 9 species (human [O15455, Q4VAL2, Q504W0], mouse [Q99MB1, Q3TM31, Q499F3], bovine [Q5TJ58, Q5TJ59], rat [Q7TNI8], buffalo [Q1G1A3], Rhesus macaque [Q3BBY1], Takifugu rubripes [Q5H721], zebrafish [Q6IWL5, Q32PW5], Japanese flounder [Q76CT7, Q76CT9]; TLR4 from 17 species (human [O00206, Q5VZI7, Q5VZI8, Q5VZI9], mouse [Q9QUK6, Q5RGT4, Q8K2T5], pig [Q68Y56, Q2TNK4, Q5F4K7, Q401C7], bovine [Q9GL65, Q6WCD5, Q8SQ55], rat [Q9QX05], hamster [Q9WV82], cat [P58727], lowland gorilla [Q8SPE8], horse [Q9MYW3], Pygmy chimpanzee [Q9TTN0], olive baboon [Q9TSP2], orangutan [Q8SPE9], Nilgai [Q2V898], American bison [Q3ZD70], dog [Q8SQH3], rabbit [AAM50060]; zebrafish [Q6NV08, Q6TS41(TLR4b)]; TLR5 from 8 species (human [O60602], pig [Q59HI7], mouse [Q9JLF7], bovine [Q2LDA0], chicken [Q4ZJ82], Japanese house mouse [Q1ZZX0], Takifugu rubripes [Q5H720, Q5H716(TLRS5)], rainbow trout [Q7ZT81]); TLR6 from 5 species (human [Q9Y2C9], mouse [Q9EPW9, Q7TPC5], rat [Q6P690], pig [Q59HI6, Q76L23], bovine [Q704V6, Q706D2]; TLR7 from 4 species (human [Q9NYK1], mouse [P58681, Q548J0], dog [Q2L4T3], Takifugu rubripes [Q5H719]); TLR8 from 4 species ((human [Q9NR97, Q495P4, Q495P6, Q495P7], mouse [P58682], pig [Q865R7], Takifugu rubripes [Q5H718]); TLR9 from 12 species (human [Q9NR96[, mouse [Q9EQU3], pig [Q5I2M3, Q865R8], bovine [Q5I2M5, Q866B2], dog [Q5I2M8], cat [Q5I2M7], Japanese flounder [Q2ABQ3], horse [Q2EEY0], sheep Q5I2M4], Ma's night monkey [Q56R09], Gilthead sea bream [Q3L273, Q3L274], Takifugu rubripes [Q5H717]]; TLR10 from two species (human [Q9BXR5, Q5FWG4, Q32MI7, Q32MI8], pig [Q4LDR6, Q59HI5]); TLR11 from mouse [Q6R5P0, Q32ME8]; TLR12 from mouse [Q6QNU9]; TLR13 from mouse [Q6R5N8]; TLR14 from Takifugu rubripes [Q5H726] and zebrafish [XP_687315]; TLR15 from chicken [ABB71177], TLR21 from Takifugu rubripes [NP_001027751], TLR22 from Takifugu rubripes [Q5H723], TLR23 from Takifugu rubripes [AAW70378], and TLR from rainbow trout [Q6KCC7, Q4LBC9], Atlantic salmon [Q2A132], goldfish [Q801F9]), Japanese lamprey [Q33E92, Q33E93] and green puffer (Fragment) [Q4S0D3]).

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Matsushima N., Tanaka T., Enkhbayar P., Mikami T., Taga M., Yamada K, & Kuroki Y. (2007). Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors. BMC Genomics, 8, 124.

Publication 2007

Atlantic salmon Bison Bovine Buffalo Chicken Cynomolgus monkey Domestic water buffalo Flounder Gilthead sea bream Goat Goldfish Gorilla Hamster Horse Human Japanese Lamprey Mouse Night monkey Olive baboon Orangutan Puffer Pygmy chimpanzee Rabbit Rainbow trout Rhesus macaque Sheep Takifugu rubripes Tlr2 Tlr5 Tlr6 Zebrafish

Corresponding Organization :

Other organizations : RMIT University, RIKEN Center for Integrative Medical Sciences, National University of Mongolia, Sapporo City University, Sapporo Medical University

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