The study design and cohort characteristics of SJLIFE have been described previously [5 (link)]. Briefly, SJLIFE is an IRB-approved institutional cohort study at SJCRH with medical, physical, psychosocial, and neurocognitive assessments conducted to characterize health-related outcomes among adult survivors of childhood cancer [5 (link)]. Eligible participants who comprise the source population include living individuals 18 years of age or older who were treated for a pediatric malignancy at SJCRH, and who were diagnosed at least 10 years before enrollment [5 (link)]. Individuals who consent to participation in SJLIFE undergo a core battery of evaluations including history and physical examination with resting heart rate, blood pressure, and 12-lead electrocardiography, and laboratory assessments including a complete blood count/differential, comprehensive metabolic panel, urinalysis, and physical performance assessment including formal evaluations of anthropometrics, body composition, aerobic capacity, sensation, flexibility, balance, muscle strength, mobility, and gross and fine motor function. In addition participants received risk-directed clinical and laboratory evaluations according to the Children’s Oncology Group Long Term Follow-up Guidelines [13 (link),14 ].