Ruxolitinib diet for infection study

Ruxolitinib (R-6688, LC Laboratories) was formulated into Nutra-gel diet (F5769-Kit, Bio-Serv) at a concentration of 1 g/kg. Mice were acclimated to untreated Nutra-gel diet (replaced daily) alongside normal rodent chow for 7 days. Mice were provided with Ruxolitinib diet or Nutra-gel diet ad libitum (replaced daily) for 2 days prior to infection and continued throughout infection study period. In experiments where mice were treated with Amphotericin B during infection, Ruxolitinib diet was added on day 18 post-infection and continued throughout the study period.

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Hargarten J.C., Ssebambulidde K., Anjum S.H., Vaughan M.J., Xu J., Song B., Ganguly A., Park Y.D., Scott T., Hammoud D.A., Olszewski M.A, & Williamson P.R. (2024). JAK/STAT Signaling Predominates in Human and Murine Fungal Post-infectious Inflammatory Response Syndrome. medRxiv.

Publication Preprint 2024

Ruxolitinib Nutra-gel diet

Corresponding Organization :

Other organizations : National Institute of Allergy and Infectious Diseases, National Institutes of Health, Makerere University, Infectious Diseases Institute, Michigan Medicine, VA Ann Arbor Healthcare System, National Institutes of Health Clinical Center

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Variable analysis

independent variables

Ruxolitinib diet
Nutra-gel diet

dependent variables

Survival/infection outcome

control variables

Normal rodent chow
Untreated Nutra-gel diet

controls

Positive control: Mice treated with Amphotericin B during infection
Negative control: Mice fed Nutra-gel diet without Ruxolitinib

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