For polygene analyses, the approximate conditional analysis from GCTA19 (link),20 (link), was used to select SNPs using a range of P value thresholds (that is, 5 × 10−8, 5 × 10−7, …, 5 × 10−3) based on summary data from the European sex-combined meta-analysis excluding TwinGene and QIMR studies. We performed a within-family prediction analysis using full-sib pairs selected from independent families (1,622 pairs from the QIMR cohort and 2,758 pairs from the TwinGene cohort) and then SNPs at each threshold were used to calculate the percentage of phenotypic variance explained and predict risk (
Polygene Analysis of Obesity Risk
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Other organizations : University of Michigan–Ann Arbor, National Cancer Institute, National Institutes of Health, University of North Carolina at Chapel Hill, Boston Children's Hospital, MRC Epidemiology Unit, University of Cambridge, University of Queensland, Harvard University, Massachusetts Institute of Technology, Broad Institute, Karolinska Institutet, Wellcome Centre for Human Genetics, University of Oxford, Science for Life Laboratory, Uppsala University, University Hospital of Lausanne, Institute of Social and Preventive Medicine, University of Tartu, University of Regensburg, University of Exeter, University Medical Center Groningen, University of Groningen, HudsonAlpha Institute for Biotechnology, Erasmus MC, The Kids Research Institute Australia, University of Western Australia, Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, University of Edinburgh, Rutgers, The State University of New Jersey, Ealing Hospital NHS Trust, Ealing Hospital, Johns Hopkins University, Johns Hopkins Medicine, Statens Serum Institut, Washington University in St. Louis, Fred Hutch Cancer Center, William Harvey Research Institute, Queen Mary University of London, University Medical Centre Mannheim, Heidelberg University, University Hospital Heidelberg, Finnish Institute for Health and Welfare, University of Hawaiʻi at Mānoa, Cancer Center of Hawaii, University of Hawaii System, Icahn School of Medicine at Mount Sinai, King's College London, QIMR Berghofer Medical Research Institute, National Institute on Aging, Institut für Medizinische Informatik, Biometrie und Epidemiologie, Lund University, Skåne University Hospital, University of Eastern Finland, Universitätsmedizin Greifswald, University Medical Center Utrecht, Centre National de la Recherche Scientifique, Université de Lille, Helmholtz Zentrum München, Pathwest Laboratory Medicine, Azienda Sanitaria di Firenze, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of San Carlos, Texas Biomedical Research Institute, Universität Ulm, IFB Adiposity Diseases, National Human Genome Research Institute, Norwegian University of Science and Technology, University of California, Los Angeles, Harokopio University of Athens, Ninewells Hospital, University of Dundee, Kaiser Permanente, University Hospital of Geneva, Glenfield Hospital, University of Leicester, University Hospital Carl Gustav Carus, TU Dresden, Umeå University, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Framingham Heart Study, National Heart Lung and Blood Institute, German Centre for Cardiovascular Research, Vrije Universiteit Amsterdam, University of Helsinki, Finnish Institute of Occupational Health, Innsbruck Medical University, Montreal Heart Institute, University of Bristol, Institute of Genetic and Biomedical Research, Sir Charles Gairdner Hospital, Life & Brain (Germany), University of Bonn, Amsterdam UMC Location VUmc, Wellcome Sanger Institute, Massachusetts General Hospital, Brigham and Women's Hospital, Medical University of Graz, University of Southern California, Icelandic Heart Association, Royal College of Surgeons in Ireland, deCODE Genetics (Iceland), Loyola University Chicago, University of Chicago, Heinrich Heine University Düsseldorf, German Center for Diabetes Research, Deutsches Diabetes-Zentrum e.V., University of Gothenburg, Erasmus University Rotterdam, Radboud University Medical Center, Radboud University Nijmegen, GlaxoSmithKline (United States), UiT The Arctic University of Norway, University College London, MRC Unit for Lifelong Health and Ageing, University College Dublin, Seoul National University, McGill University, Columbia University, RIKEN Center for Integrative Medical Sciences, Korea National Institute of Health, Yale University, Howard Hughes Medical Institute, Queen's University Belfast, Imperial College London, Genome Institute of Singapore, Agency for Science, Technology and Research, Aalto University, Tokyo Medical and Dental University, Université de Strasbourg, Cedars-Sinai Medical Center, University of Lausanne, University of Milano-Bicocca, Center for Human Genetics, Vanderbilt University Medical Center, University of Milan, University of Glasgow, Deutsches Herzzentrum München, West German Heart and Vascular Center Essen, University of Pisa, Hôpital Rangueil, University of the West Indies, NorthShore University HealthSystem, University of Leeds, Eurac Research, University of Lübeck, Academic Medical Center, University of Utah, University of South Australia, Science Applications International Corporation (United States), Institute for Molecular Medicine Finland, University of Oulu, Kuopio University Hospital, Fimlab (Finland), Tampere University, Steno Diabetes Center, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, University of Washington, University of Iowa, Illumina (United Kingdom), Turku University Hospital, Pennington Biomedical Research Center, Pennsylvania State University, South Karelia Central Hospital, University of Maryland, Baltimore, Helsinki University Hospital, Leipzig University, Université Paris Cité, Sorbonne Université, Centro Cardiologico Monzino, Inserm, Institut Pasteur de Lille, Stanford University, Nanyang Technological University, The University of Texas Health Science Center at Houston, Albert Einstein College of Medicine, Wake Forest University, Centre for Medical Systems Biology, Finnish Diabetes Association, Netherlands Heart Institute, Newcastle University, Ludwig-Maximilians-Universität München, King Abdulaziz University, St George's, University of London, Addenbrooke's Hospital
Protocol cited in 165 other protocols
Variable analysis
- P value thresholds (5 × 10^-8, 5 × 10^-7, ..., 5 × 10^-3)
- Mean BMI
- Ability to predict obesity (BMI ≥ 30 kg m^-2) using the c statistic from logistic regression models
- Percentage of phenotypic variance explained
- Risk prediction
- European sex-combined meta-analysis excluding TwinGene and QIMR studies
- Full-sib pairs selected from independent families (1,622 pairs from the QIMR cohort and 2,758 pairs from the TwinGene cohort)
- Independent sample of unrelated individuals from the TwinGene (n = 5,668) and QIMR (n = 3,953) studies
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