For the semi-automatic segmentation work in this study we used 3D Slicer 4.0, which is freely downloadable from the website http://www.slicer.org .
Manual segmentation of each data set was performed on a slice-by-slice basis by neurosurgeons at the University Hospital of Marburg in Germany (Chairman: Prof. Dr. Ch. Nimsky) with several years of experience in the resection of gliomas (note: if the tumor border was very similar between consecutive slices, the software allowed the user to skip manual segmentation in each slice, and instead interpolated the boundaries in these areas). The software used for this manual contouring provided simple contouring capabilities, and was created by us using the medical prototyping platform MeVisLab (seehttp://www.mevislab.de/ ). The hardware platform used was an Intel Core i5-750 CPU, 4 × 2.66 GHz, 8 GB RAM, Windows XP Professional ×64 Version, Version 2003, Service Pack 2.
Manual segmentation of each data set was performed on a slice-by-slice basis by neurosurgeons at the University Hospital of Marburg in Germany (Chairman: Prof. Dr. Ch. Nimsky) with several years of experience in the resection of gliomas (note: if the tumor border was very similar between consecutive slices, the software allowed the user to skip manual segmentation in each slice, and instead interpolated the boundaries in these areas). The software used for this manual contouring provided simple contouring capabilities, and was created by us using the medical prototyping platform MeVisLab (see
