C57BL/6J (WT) mice were purchased from The Jackson Laboratory. Mice deficient in the type I IFN receptor (CD118-/-) (29 (link)) or HSV glycoprotein B (gB)T-I.1 TCR transgenic mice (30 (link)) on a WT background were maintained at Dean McGee Eye Institute. Animal treatment was consistent with the National Institutes of Health Guidelines on the Care and Use of Laboratory Animals. All procedures were approved by the University of Oklahoma Health Sciences Center and Dean A. McGee Eye Institute Institutional Animal and Care Use Committee. HSV-1 (strain McKrae) was grown and maintained as previously described (31 (link)).
Protocol detail
Mice Models for Viral Infection Studies
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Animal
Cd118
Glycoprotein
Hsv 1
Laboratory animals
Mice
Strain
Transgenic mice
Type i ifn
Corresponding Organization :
Other organizations : Bipar, University of Oklahoma Health Sciences Center
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Variable analysis
independent variables
- Mouse genotype: WT, CD118-/- (type I IFN receptor deficient), gB T-I.1 TCR transgenic
- Not explicitly mentioned
- WT background for CD118-/- and gB T-I.1 TCR transgenic mice
- Animal treatment consistent with NIH Guidelines on the Care and Use of Laboratory Animals
- Positive control: WT (C57BL/6J) mice
- Negative control: Not specified
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